Tendons
Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic approach for treating tendon tears, with several clinical trials demonstrating measurable improvements in tissue healing and functional outcomes. The clinical evidence shows that MSCs can enhance tendon repair through various mechanisms, though research continues to refine optimal treatment protocols.
Hips
Intra-articular injections of mesenchymal stem cells (MSCs) into the hip joint are an emerging treatment approach primarily studied for hip osteoarthritis (OA). Clinical trials and small studies indicate this therapy is generally safe and shows promising effectiveness in reducing pain and improving function, although definitive evidence from large randomized controlled trials (RCTs) is still lacking.
Ankles
Pain Reduction and Functional Improvement: Clinical studies report significant improvements in pain scores such as the Visual Analog Scale (VAS) and functional mobility measures like the Ankle Osteoarthritis Scale (AOS) and Foot and Ankle Ability Measure (FAAM) up to one year post-treatment with MSC therapy.
Tendons
Mesenchymal stem cells (MSCs) have been investigated in clinical trials as a treatment for torn tendons, particularly partial tendon tears such as those in the supraspinatus (rotator cuff) or Achilles tendon. Several studies have explored the safety, efficacy, and potential regenerative effects of injecting MSCs directly into tendon lesions.
Macrophages and their M2 polarization driven by MSC immunomodulatory actions play a particularly important role in tendinopathy resolution.
Mesenchymal stem cells (MSCs) are extensively studied in clinical trials for treating heart diseases, particularly heart failure and ischemic heart disease. These trials focus on the safety, efficacy, and mechanisms by which MSCs may regenerate damaged cardiac tissue, improve heart function, and reduce fibrosis and inflammation.
Heart Disease
Mesenchymal stem cells (MSCs) are extensively studied in clinical trials for treating heart diseases, particularly heart failure and ischemic heart disease. These trials focus on the safety, efficacy, and mechanisms by which MSCs may regenerate damaged cardiac tissue, improve heart function, and reduce fibrosis and inflammation.
Clinical l trial
Type 1 Diabetes and Focal Epilepsy
MScs treating Felbamate add-on therapy for drug-resistant focal epilepsy
All injections contain 22.5 million live cells derived from umbilical cord blood. These are the most effective MSCs. These MSCs cells have never been frozen and are the most effective in any treatments
Knees
Multiple randomized controlled trials (RCTs) and meta-analyses report that intra-articular MSC injections lead to significant improvements in pain (e.g., WOMAC, VAS scores), knee function, and sometimes cartilage regeneration or preservation in OA patients. These improvements are often seen within 6 to 12 months post-injection and may last longer.
Concussions
Clinical trials investigating mesenchymal stem cells (MSCs) for the treatment of concussions and traumatic brain injury (TBI) have primarily focused on safety, functional recovery, and neuroprotection. While most studies target moderate to severe TBI, the underlying mechanisms and outcomes are relevant to concussion management, especially in cases with persistent symptoms or post-concussion syndrome.
https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1472679/full
Pain
Pain Reduction and Functional Improvement: Clinical studies report significant improvements in pain scores such as the Visual Analog Scale (VAS) and functional mobility measures like the Ankle Osteoarthritis Scale (AOS) and Foot and Ankle Ability Measure (FAAM) up to one year post-treatment with MSC therapy.
Hip
Intra-articular injections of mesenchymal stem cells (MSCs) into the hip joint are an emerging treatment approach primarily studied for hip osteoarthritis (OA). Clinical trials and small studies indicate this therapy is generally safe and shows promising effectiveness in reducing pain and improving function, although definitive evidence from large randomized controlled trials (RCTs).
Heart Disease
Mesenchymal stem cells (MSCs) are extensively studied in clinical trials for treating heart diseases, particularly heart failure and ischemic heart disease. These trials focus on the safety, efficacy, and mechanisms by which MSCs may regenerate damaged cardiac tissue, improve heart function, and reduce fibrosis and inflammation.
Clinical trial